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Jones, J.O., Bolton, E.C., Huang, Y., Feau, C., Guy, R.K., Yamamoto, K.R., Hann, B., Diamond, M.I. (2009) Non-competitive androgen receptor inhibition in vitro and in vivo. Proc Natl Acad Sci USA. 106, 7233-7238. PDF
Meijsing, S.H., Pufall, M.A., So, A.Y., Bates, D.L., Chen, L., Yamamoto, K.R. (2009) DNA-binding site sequence directs glucocorticoid receptor structure and activity. Science 324, 407-410 PDF
Pantoja, C., Huff, J.T., Yamamoto, K.R. (2008) Glucocorticoid Signaling Defines a Novel Commitment State during Adipogenesis In Vitro. Mol. Biol. Cell. 19, 4032-41 PDF
Taubert, S., Hansen, M., Van Gilst, M.R., Cooper, S.M., Yamamoto, K.R. (2008) The Mediator Subunit MDT-15 Confers Metabolic Adaptation to Ingested Material. PLoS Genetics 4, e1000021 PDF
So, A.Y., Cooper, S.B., Feldman, B.J., Manuchehri, M., Yamamoto, K.R. (2008) Conservation Analysis Predicts In Vivo Occupancy of Glucocorticoid Receptor Binding Sequences at Glucocorticoid-Induced Genes. Proc. Natl. Acad. Sci. USA 105; 5745-5749. PDF
So, A.Y., Chaivorapol, C., Bolton, E.C., Li, H., and Yamamoto, K.R. (2007) Determinants of Cell- and Gene-Specific Transcriptional Regulation by the Glucocorticoid Receptor. PloS Genetics 3, e94. PDF
Bolton, E.C., So, A.Y., Chaivorapol, C., Haqq, C.M., Li, H. and Yamamoto. K.R. (2007) Cell- and Gene-Specific Regulation of Primary Target Genes by the Androgen Receptor. Genes Dev, 21, 2005-2017. PDF
Woodruff, P.G., Boushey, H.A., Dolganov, G.M., Barker, C.S., Yang, Y.H., Donnelly, S., Ellwanger, A., Sidhu, S.S., Dao-Pick, T.P., Pantoja, C., Erle, D.J., Yamamoto, K.R., Fahy,. J.V. (2007) Genome-Wide Profiling Identifies Epithelial Cell Genes Associated With Asthma and With Treatment Response to Corticosteroids. Proc. Natl. Acad. Sci. USA 104, 15858-15863. PDF
Ricketson, D., Hostick, U., Fang, L., Yamamoto, K.R., and Darimont, B. A conformational switch in the ligand binding domain regulates the dependence of the glucocorticoid receptor on Hsp90. J Mol Biol. 2007 May 4;368(3):729-41. PDF
Meijsing, S.H., Elbi, C., Luecke, H.F., Hager, G.L., and Yamamoto, K.R. (2007) The ligand binding domain controls Glucocorticoid receptor dynamics independent of ligand release. Mol Cell Biol. 2007 Apr;27(7):2442-51. PDF
Feldman, B.F., Streeper, R.S., Farese, R.V. Jr. and Yamamoto, K.R. (2006) Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proc. Natl. Acad. Sci. USA 103, 15675-15680. PDF
Taubert, S., Van Gilst, M.R., Hansen, M., Yamamoto, K.R. (2006) A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. Genes Dev. 20, 1137-1149. PDF
Wang, J-C., Shah, N., Pantoja, C., Meijsing, S.H., Ho, J.D., Scanlan, T.S., Yamamoto, K.R. (2006) Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity. Genes Dev.20, 689-699. PDF
Van Gilst, M.R., Hadjivassiliou, H., and Yamamoto, K.R. (2005) A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49. Proc. Natl. Acad. Sci. USA 102, 13496-13501. PDF
Luecke, H.F. and Yamamoto, K.R. (2005). The Glucocorticoid Receptor blocks P-TEFb recruitment by NFkB to effect promoter specific transcriptional repression. Genes Dev. 19, 1116-1127. PDF
Shostak, Y. and Yamamoto, K.R. (2005) Overlapping but Separable Determinants of DNA Binding and Nuclear Localization Map to the C-terminal End of the C. elegans DAF-12 DNA Binding Domain. J. Biol. Chem.
280, 6554-6560. PDF
Van Gilst, M.R., Hadjivassiliou, H., Jolly, A., and Yamamoto, K.R. (2005) Nuclear Hormone Receptor NHR-49 Controls Fat Consumption and Fatty Acid Composition in C. elegans. PLoS Biol. 3, e53. PDF
Wang, J-C., Derynck, M.K., Nonaka, D..F, Khodabakhsh, D.B., Haqq, C., Yamamoto, K.R. (2004) Chromatin Immunoprecipitation (ChIP) Scanning Identifies Primary Glucocorticoid Receptor Target Genes. Proc. Natl. Acad. Sci. USA 101, 15603-15608. PDF
Shostak, Y., Van Gilst, M.R., Antebi, A., and Yamamoto, K.R. (2004). Identification of C. elegans DAF-12 binding sites, response elements and target genes. Genes Dev. 18, 2529-2544. PDF
Wang, J-C., Walker, A., Blackwell, T.K., and Yamamoto, K.R. (2004) The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis. J. Biol. Chem. 279, 29270-29277. PDF
Freedman N.D. and Yamamoto K.R. (2004) Importin 7 and Importin a/Importin
b Are Nuclear Import Receptors for the Glucocorticoid
Receptor. Mol. Biol. Cell 15, 2276-2286. PDF
Kian Tee, M., Rogatsky, I., Tzagarakis-Foster, C., Cvoro, A., An, J., Christy, R.J., Yamamoto, K.R. and Leitman, D.C. (2004) Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors a and b. Mol. Biol. Cell 15, 1262-1272. PDF
Rogatsky, I., Wang, J-C., Derynck, M.K., Nonaka, D., Khodabakhsh, D.B., Haqq, C.M., Darimont, B.D., Garabedian, M.J., and Yamamoto, K.R. (2003) Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor. Proc. Natl. Acad. Sci. USA 100, 13845-13850. PDF
Rogatsky, I., Luecke, H.F., Leitman, D.C., Yamamoto, K.R. (2002) Alternate
surfaces of transcriptional co-regulator GRIP1 function in
different glucocorticoid receptor activation and repression
contexts. Proc. Natl. Acad. Sci. USA. 99, 16701-16706. PDF
Freeman,
B.C., Yamamoto, K.R. (2002) Disassembly of transcriptional regulatory
complexes by molecular chaperones. Science 296, 2232-2235.
PDF
Rogatsky,
I., Zarember, K.A., Yamamoto, K.R. (2001) Factor recruitment and
TIF2/GRIP1 corepressor activity at a collagenase-3 response
element that mediates regulation by phorbol esters and hormones.
EMBO J. 20, 6071-6083.
PDF
Freeman,
B.C., Yamamoto, K.R. (2001) Continuous recycling: a mechanism for
modulatory signal transduction. Trends Biochem Sci.
26, 285-290. PDF
Sitcheran,
R., Emter, R., Kralli, A., Yamamoto, K.R. (2000) A genetic analysis
of glucocorticoid receptor signaling: Identification and characterization
of ligand-effect modulators in Saccharomyces cerevisiae. Genetics 156, 963-972.
PDF
Nissen,
R.M., Yamamoto, K.R. (2000) The glucocorticoid receptor inhibits
NFkappaB by interfering with serine-2 phosphorylation of the
RNA polymerase II carboxy-terminal domain. Genes Dev.
14, 2314-2329.
PDF
van
Tilborg, M.A., Lefstin, J.A., Kruiskamp, M., Teuben, J., Boelens, R.,
Yamamoto, K.R., Kaptein, R. (2000) Mutations in the glucocorticoid
receptor DNA-binding domain mimic an allosteric effect of
DNA. J. Mol. Biol. 301, 947-958.
PDF
Jamieson,
C.A., Yamamoto, K.R. (2000) Crosstalk pathway for inhibition of
glucocorticoid-induced apoptosis by T cell
receptor signaling.
Proc. Natl. Acad. Sci. USA. 97, 7319-7324.
PDF
Freeman,
B.C., Felts, S.J., Toft, D.O., Yamamoto, K.R. (2000) The p23 molecular
chaperones act at a late step in intracellular receptor action
to differentially affect ligand efficacies. Genes Dev.
14, 422-434.
PDF
Diamond,
M.I., Robinson, M.R., Yamamoto, K.R. (2000) Regulation of expanded
polyglutamine protein aggregation and nuclear localization
by the glucocorticoid receptor. Proc. Natl. Acad. Sci. USA 97, 657-661.
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